Hopeful

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  1. Agree
    Hopeful reacted to Bkkandrew in And it's an own goal!   
    Perfect time to sequestrate the assets of these sports “stars” worldwide and return to a more gentlemanly way of playing and watching sport.
  2. Agree
    Hopeful reacted to Covid19 and life to go in On which side of the bed do you sleep?   
    Nearest the door.
  3. Agree
    Hopeful got a reaction from Mirror Mirror in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Better and coronavirus clear after a week
    he's having a larf
    at our expense
  4. Agree
    Hopeful got a reaction from Erewhon888 in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    It's pretty straightforward to do if you know what you are doing,
    But rt-PCR at this scale would need to be on a robotic system I'd have thought.
    I've just looked at a kit https://www.biobasic.com/coronavirus-covid-19-primers#kit
    It's bog standard GTC extraction, spin column and RT-PCR
    And for a few tests it would be fine,
    But imagine scaling this kit up in a lab with technicians - chaos.
    That kit is pretty useless. Still the company is trying to have a presence I guess.
    (Be simpler and cheaper to DIY your own 'kit' for a test of course - primers are cheap as chips. I wonder how many Mol Biol bods are testing themselves, I've got all the equipment and I'm tempted.... but won't probably bother.)
     
  5. Agree
    Hopeful reacted to Melchett in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    I had pneumonia when I was a toddler - bad enough that my parents were told I wouldnt survive the night at one point. I am now a fit, healthy 54 year old, in better shape AFAICS than most most guys in their 30s. Yes, it caused me lifelong loss of lung function, such that I could never have been a great athlete, but frankly, that's no big loss. I get by more than well enough. I ran cross country for the county and competed at national level in cycle races as a teenager, I was just never going to be a contender. 
    Of course if you arent prepared to do as I do and live a clean and healthy life, maybe it would fuck you up really badly? And there in lies the problem for most of the population....
  6. Agree
    Hopeful got a reaction from onlyme in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    We already have full English campuses in China
    Nottingham Uni has a replica campus in Ningbo
    All par of our courting China
  7. Agree
    Hopeful got a reaction from Rowley in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Afraid, it's too depresing to watch that, knowing it may be impossible to repeat
  8. Agree
  9. Agree
    Hopeful reacted to mattydread in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Agreed.
    I can't see anything optimistic about any of this for the long term.
    Was expecting to semi retire/travel in 4 or 5 years (after much hard work in my small business) that's gone off a cliff the last 2- 3 weeks.
    I'm a bit more confident in the outcome in Aus though with the lower infection/death rate (small population in general) Family & friends mainly in UK which I worry about (along with fellow dosbod family)
    I suppose we'll see which direction this will pan out in the next 2 months..shitstorm or Megafucked.
    It won't be pretty or end well either way imo.
     
  10. Agree
    Hopeful got a reaction from Kilham in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Afraid, it's too depresing to watch that, knowing it may be impossible to repeat
  11. Informative
    Hopeful got a reaction from The Masked Tulip in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    We already have full English campuses in China
    Nottingham Uni has a replica campus in Ningbo
    All par of our courting China
  12. Agree
    Hopeful got a reaction from Kilham in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Unfortunately, I fear so
    It's such a fucking shame that Blair wrecked this country so successfully.
    It wouldn't have been that bad to be a prisoner here, I could have coped
    Now, it's fucking rubbish
    The thiught I can't escape, even for a few weeks, is now quite worrying.
  13. Agree
    Hopeful got a reaction from The Idiocrat in Coronavirus Cookery   
    Very good
    More weeds you can eat here
    https://www.eatweeds.co.uk/plants
    We have wild garlic mayonnaise with deep-fried tempura battered squid tonight
    Might have nettle soup first.
  14. Agree
    Hopeful got a reaction from Chewing Grass in Coronavirus Cookery   
    Very good
    More weeds you can eat here
    https://www.eatweeds.co.uk/plants
    We have wild garlic mayonnaise with deep-fried tempura battered squid tonight
    Might have nettle soup first.
  15. Agree
    Hopeful got a reaction from null; in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    For that we need deaths, probably a lot of deaths
    Or everyone that has a deadly strain has to be identified and isolated so that the virus is effectively removed.
  16. Agree
    Hopeful got a reaction from BBH in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    ^ this
  17. Agree
    Hopeful reacted to Rowley in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    They were probably all wearing masks to start off with
  18. Agree
    Hopeful got a reaction from eight in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Yes, but you can't rely upon genetic drift to fix the new mutation in the population, it could drift to fixation, it could disappear
    You need selection to drive a new strain to prevalence or fixation.
    Selection that favours its spread.
    It could be fitter because it is more infectious than a previous strain, for example, while being equally lethal or less lethal
    or it could succeed because an earlier more lethal strain is selected against because the hosts die more quickly and a dead host doesn't transmit virus.
    The new strain should have a fitness advantage.
     
  19. Agree
    Hopeful reacted to spygirl in And it's an own goal!   
    https://www.dailymail.co.uk/news/article-8183453/Gary-Lineker-blasts-Matt-Hancock-demand-footballers-rush-coronavirus-pay-cuts.html
    Oh dear.
    Spanish have cut.
    Time to start a campaign to sack Lineker
  20. Agree
    Hopeful got a reaction from AlfredTheLittle in Knocked up at 48!   
    £700k if both end up in care for 5 years, which they likely will. I have  a distinct feeling that fees have risen to property values. Just like rents have risen to housing benefit levels.
  21. Agree
    Hopeful got a reaction from Austin Allegro in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    ^ this
  22. Agree
    Hopeful got a reaction from onlyme in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    It's pretty straightforward to do if you know what you are doing,
    But rt-PCR at this scale would need to be on a robotic system I'd have thought.
    I've just looked at a kit https://www.biobasic.com/coronavirus-covid-19-primers#kit
    It's bog standard GTC extraction, spin column and RT-PCR
    And for a few tests it would be fine,
    But imagine scaling this kit up in a lab with technicians - chaos.
    That kit is pretty useless. Still the company is trying to have a presence I guess.
    (Be simpler and cheaper to DIY your own 'kit' for a test of course - primers are cheap as chips. I wonder how many Mol Biol bods are testing themselves, I've got all the equipment and I'm tempted.... but won't probably bother.)
     
  23. Agree
    Hopeful got a reaction from longtomsilver in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Yes, but you can't rely upon genetic drift to fix the new mutation in the population, it could drift to fixation, it could disappear
    You need selection to drive a new strain to prevalence or fixation.
    Selection that favours its spread.
    It could be fitter because it is more infectious than a previous strain, for example, while being equally lethal or less lethal
    or it could succeed because an earlier more lethal strain is selected against because the hosts die more quickly and a dead host doesn't transmit virus.
    The new strain should have a fitness advantage.
     
  24. Agree
    Hopeful got a reaction from Hail the Tripod in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Yes, but you can't rely upon genetic drift to fix the new mutation in the population, it could drift to fixation, it could disappear
    You need selection to drive a new strain to prevalence or fixation.
    Selection that favours its spread.
    It could be fitter because it is more infectious than a previous strain, for example, while being equally lethal or less lethal
    or it could succeed because an earlier more lethal strain is selected against because the hosts die more quickly and a dead host doesn't transmit virus.
    The new strain should have a fitness advantage.
     
  25. Agree
    Hopeful got a reaction from Melchett in Pandemic coming? - Coronavirus April 2020 (Part 3)   
    Yes, but you can't rely upon genetic drift to fix the new mutation in the population, it could drift to fixation, it could disappear
    You need selection to drive a new strain to prevalence or fixation.
    Selection that favours its spread.
    It could be fitter because it is more infectious than a previous strain, for example, while being equally lethal or less lethal
    or it could succeed because an earlier more lethal strain is selected against because the hosts die more quickly and a dead host doesn't transmit virus.
    The new strain should have a fitness advantage.